I am the Storyteller for our Werewolf game, and I've ST'd Vampire before. With Vampire, I think it works best when there's an open world filled with political intrigue and nefarious plots and a sense of the weight of centuries. Tracking all of those...
Those games are harder to balance, too, because the slow descent into being a bad guy can be disheartening, but being a vampire superhero feels like a betrayal of the genre. I think there's a good way to do it...or maybe my friends just don't really want to experience the shameful slide into darkness, lol. We prefer to be werewolf superheroes trying to save the world while fighting our dark sides.