I think istitutions and professionals embraced 24/7 crypto market by now. Also, they heavily relate on bots and trading algos - more than casual folk. So, i wouldn't be so sure who is present at market on weekends.
Thin in terms of organic volume.
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Personally I think the influence of bots and algos is overstated. They are just tools and I'd expect most would still need some babysitting or dead mans lever and so they might not be running on weekends.