I've been thinking about life extension technology a lot lately, CRISPR definitely falls into line along this line of thought. Besides the clear ethical issues that could arise, and the inevitability that once this tech is available - people will be using it for all manners of life enhancement modifications; what has got me all twisted up is the spiritual questions this will present.
Some people take the perspective that people should dance with the one that brought them, in other words, maybe WE CHOSE to incarnate with these issues/diseases because it offers the soul (or whatever part of us extends beyond the material) the chance to grow. Another twist on this would be how it interplays with karma and/or reincarnation.
Similarly, if people start being able to live forever in this body or AI/Robots or whatever, is there something that we're missing out on regarding post-bodily-death? As if you were playing a video game and ingame found a way for your avatar to never logout because you forgot you were playing a game.

Maybe there is no GAME OVER