This is an excellent article - as expected.

This shows a not very well understood problem. Even most academics don´t get this. It is called non-ergodicity.

Russian roulette: - a 10000-chamber revolver and only one bullet. You can win what ever you wish. For you, it is very unlikely that you catch a bullet and for a super-majority of people it is also very unlikely that they catch a bullet. If the ensemble is big enough some will die. All in all the upside for the population is massive.

For the individual, a non zero probability of an irreversible loss aka ruin is something which should make clear - >>don´t take this bet<<. From the individual perspective NO One should take it <--> from the ensemble perspective everyone should take it.

I mean, Covid looks like a nail and hydroxychloroquine is a hammer. Lupus is a nail, malaria is a nail, Covid looks like a nail. When you don´t take it --> you die with >0 zero probability and when you take it, --> you loose your vision with >0 probability. Life>vision ...thats the normal logic behind medicine I guess.

However, often it is very easy and cheap to establish tissue selectivity and reduce off-target effects. Take chemo-therapy sessions: People say "hairs will grow back". Of course I would not think twice and take the therapy. But we know that during the short session it would be enough to simply cool down the scalp to 6°C/40°F...still no one uses this technique. And loosing your vision comes for most people right before losing your life...big pharma does not spend much money on compliance issues.

Have a great weekend!