Interesting stuff! Amazing that this cell line is being involved invitro for over 50 years. What will be the goal of comparing the transfected HL-60s with healthy human and sepsis patient neutrophils?
Interesting stuff! Amazing that this cell line is being involved invitro for over 50 years. What will be the goal of comparing the transfected HL-60s with healthy human and sepsis patient neutrophils?
Great question! Comparing the results from previous experiments with healthy donors and sepsis patients to the new experiments with the HL-60s may help prove that the upregulation of this protein affects immune function in some way. It's more of a proof of concept that this protein is increased during sepsis.
This protein may serve as an indicator or biomarker for sepsis. We're talking years into the future here, but imagine a test with one drop of blood from the tip of one's finger onto an test strip that would tell a physician within seconds that a patient is septic. Cool huh?
Here's a very interesting article from 2019 describing another way that scientists are trying to beat the clock against sepsis and septic shock. https://www.bbc.com/news/uk-wales-49677463