I use evolutionary biology to reconstruct the evolutionary path of caspase proteins. I want to understand how discrete regulatory mechanisms evolved among the 12 human caspases, so that we can potentially manipulate them with rationally designed drugs.
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Got ya! So you compare the structures of caspases with Xray crystallography and then try to find substrate analogues with high throughput screening?
I am following you now! It would be cool if you would maybe look at my blog also. I am not asking for upvotes or you following me, just suggestions and ideas!
Cheers!
followed. I compare the amino acid sequences of all caspases, including rat, bat, cat, ect... and then predict the sequence of the common ancestor. Then I resurrect the ancestral gene and crystallize it
That is very cool! Chemistry is so fascinating. I may end up going into the development of new instruments. Anyways, good luck! Cheers!