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With the use of TALENS and CRISPR, genotype editing in human pleuropotent atem cells has met some sucess but has some shortcomings as well.

I read somewhere that a complete bone marrow transplant can end up changing a patients genotype all together.. What is your take on this.?

No that ia not true.
BMT can cure diseases like sickle cell anemia.it means that BMT has altered genotype in context of blood. But in the same patient, there are numerous other functions going on which are carried by other genes to which BM has no link.

OK. Got it. Thanks for your replies.