Wow, 5000 years old, that's pretty amazing! I've read, that it was quite popular from prehistoric times onward to either try bringing back people to life or releasing "evil spirits" of abnormal behaving people.

This painting by Hieronymus Bosch also deals with trepanation:

Detail from The Extraction of the Stone of Madness, a painting by Hieronymus Bosch depicting trepanation (ca. 1488–1516) - CC0

Very remarkable, that you can remember the skull from your childhood and even your daughter is fascinated by it. Now I'm too, thanks for sharing it with me :-)