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Thanks, I know and love Dune :) I'm not sure what I'd call my favorite SF universe. There are just too many. Maybe Hannu Rajaniemi's Quantum Thief trilogy. Because it's based on some wild posthuman stuff from 19th century Russian philosophers.

https://en.wikipedia.org/wiki/Nikolai_Fyodorovich_Fyodorov
https://en.wikipedia.org/wiki/Sobornost