Genetic engineering has the ability to manipulate specific genes so its expression can be controlled.
The control of gene expression can be used as a gene functional for appropriate purposes, such as
diseases cure with gene therapy. This therapy involves DNA as nucleic acid which is transfer to
embryonic or somatic cells of patients with certain diseases. The purpose of the gene therapy is to
switch an abnormal gene to be a functional gene which has a cure effect for the disease. The
functional gene has to substitute the abnormal gene leads to certain disease, either germ line gene
therapy or somatic cells therapy. The gene therapy needs a vector to carry the functional gene to
targeted cells, in vivo or ex vivo. The vector can be used viral or non viral vectors. The possibilities
of achievement of its therapy depend on gene transfer effectiveness and also functional gene
expression. The cancer is the one of diseases which can be treated with the gene therapy due to its
uncontrolled gene of cell proliferation