Wow, I hadn't heard of PANDAS. Thank you. About medications, it always depends on the case. In conditions that involve a noticeable alteration of personality and/or behavior, however, most medications treat symptoms, not the underlying causes, since these are too hard to pin point and can be the result of more than one factor. For example in schizophrenia, bipolar disorder, and stimulant psychosis, medications will try to block your dopamine receptors, but why were they messed up in the first place? Unfortunately many diseases do not have a direct cure yet even if you do know the cause, and you can only repair the damage without directly attacking what caused it, or just alleviate the symptoms for a better quality of life.