Looking forward to reading. This is one of my favorite subjects to contemplate. I remember the arsenic life form mistake that happened a few years ago.. It was found not to be true, though the organism thrived on arsenic which kills us.. so basically I'm saying there might be other elements yet. Maybe some that we don't even know about. So many variables in the Fermi paradox. And I lean towards the self destruction answer. Based on where the Earth is heading and how our history looks
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I think they actually found a life form that had one of the elements in DNA replaced with arsenic. I think it was phosphorus that was replaced in this life form.
They couldnt find any arsenic in its DNA. I looked up a few articles before I posted this! But there is something strange about it since it thrives off something fatal to carbon based lifeforms. But regardless, look forward to going through the Fermi paradox and learning some new things!