if we're going to be selfish anyways (which I think is a fairly consistent trait in humans), far better to be selfishly helpful to others than selfishly hurtful. Which i think of as (or hope for) the world moving from a competitive framework to a co-operative one.
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I think the idea of self-interested over "selfish" which specifically excludes caring about others. Self-interested recognizes it's my responsibility to take care of me and no one else has that responsibility but me. Once I do that, I'm in a much better place to take care of others who for whatever reason are unable to take care of themselves.