Great post. I think the big vs small debate and the topic of that relationship correlating with the risk tolerance of an institution is spot on. Huge dinosaurs don't pivot on a dime.
However, I think your juxtaposition of the Smithsonian to the William Way Center speaks more to audience and different definitions of "public."
In DC the exhibits need to be broad and innocuous. At the William Way Center, off the tourist track in downtown Philly, the art has free reign because its within a safe LGBTQI space. So both spaces invite different variations of the public in terms of scale and diversity.
Non-profits are strange beasts and when you boil them all down, they are people driven organizations steered by a Board of Trustees.
Big Board = lots of egos, small Board = slightly fewer.
Thus, more people, more problems.
Here's my take on the topic: https://steemit.com/nonprofit/@peartree4/cryptocurrencies-and-non-profit-organizations-fad-or-future