No vaccine or medicine can prevent African sleeping sickness. But you can avoid being bitten by tsetse flies. Experts recommend the following:

Wear protective clothing, such as long-sleeved shirts and pants. Tsetse flies can bite through material, so clothing should be made of thick fabric.

Wear khaki, olive, or other neutral-colored clothing. Tsetse flies are attracted to bright and dark contrasting colors.

Use bed nets when sleeping.

Look inside vehicles for tsetse flies before getting into them.

Do not ride in the back of jeeps, pickup trucks, or other open vehicles. Tsetse flies are attracted to the dust created by moving vehicles and animals.

Stay away from bushes. During the hottest part of the day, the tsetse fly will rest in bushes. But they will bite if disturbed.