secretin stimulation test

Secretin stimulation test is used to confirm the diagnosis of Zollinger-Ellison syndrome (ZES) in those with an unequivocal serum gastrin level.

In this test, a bolus of secretin is administered after an overnight fast, and serum gastrin levels are then determined.

This provocative test is able to differentiate the diagnosis of ZES from other conditions that may produce an elevated serum gastrin level such as renal failure, gastric outlet obstruction or those on antisecretory therapy.

This test should only be performed after the serum fasting gastrin level is obtained to confirm non diagnostic results.