Chemical Of The Week #1 - Carbidopa...and Introduction!

in #introduceyourself6 years ago (edited)

20190326_215928.jpg
3D model of Carbidopa

Hi,

I made this account to share cool information about some of the chemicals we use, and also teach people a few things about chemistry. I have always been fascinated by the pharmacology of Carbidopa, so it is my first entry! I hope you all enjoy it, and you can expect a post every week on an interesting chemical. I am open to suggestions! Please do not hesitate to ask questions too, I have a lot of background in chemistry and like explaining things in less convoluted ways!

Chemical Of The Week 1. Carbidopa

Chemical Identifier #. 34359
Empirical Formula: C10H14N2O4
Molecular Weight: 226.23
Synonyms: Lodosin, Lodosyn, Methyldopahydrazine, MK 485

Carbidopa is a drug used in the treatment of Parkinsons, usually in conjunction with Levodopa (aka L- Dopa). It functions by blocking the conversion of L-Dopa to Dopamine by Dopa decarboxylase. This may seem odd because you want more Dopamine in the brain. However it cannot cross the blood brain barrier, but L-dopa can, where it then is converted to Dopamine in the Substantia Nigra.

George Cotzias, a Greek-American scientist, is credited with the discovery of the ability of Carbidopas to increase the effectiveness of Parkinsons treatment with Levodopa. He also made the critical observation that Parkinsons symptoms decreased when Levodopa was administrated in increasing dosages over time.

Carbidopa became commercially available in 1975.

carbidopa.jpg
Line drawing structure of Carbidopa

References:

https://pubchem.ncbi.nlm.nih.gov/compound/carbidopa

https://www.ncbi.nlm.nih.gov/pubmed/9633679

https://medlineplus.gov/druginfo/meds/a601068.html

https://en.wikipedia.org/wiki/Carbidopa

George Cotzias
https://en.wikipedia.org/wiki/George_Cotzias

Sort:  

Chemistry question:
Can acyl azides be prepared from carboxylic acids without activation of the carboxyl group (acyl chloride, anhydride, carbodiimide, active ester, etc.)? I’m preparing a precursor for Curtius rearrangement and hydrolysis to prepare the amine with one less C. (No other sensitive functional groups are present). Have you ever heard of cesium fluoride being used in this context? I know the best approach is to use DPPA, but interested in other options.

Boy, it has been a long while since I have done any synthesis. Let me get back to you, I wanna take a peak at the Beilstein manuals. They must be online somewhere.

Do you have access to a university or institutional library account? I would like some PDFs of some of my publications for my records.

I wish. Sounds like you need to friend a student at a university.

Posted using Partiko Android

Chemistry question:
Can acyl azides be prepared from carboxylic acids without activation of the carboxyl group (acyl chloride, anhydride, carbodiimide, active ester, etc.)? I’m preparing a precursor for Curtius rearrangement and hydrolysis to prepare the amine with one less C. (No other sensitive functional groups are present). Have you ever heard of cesium fluoride being used in this context? I know the best approach is to use DPPA, but interested in other options.

Hello chemicalweek,
This is not an automated answer its ME and welcome to Steemit.
You are a Steemian now with two accounts !
And your first blog for this account is online. Great, and I'm sure one day we will say those were the very early days of Steemit, so congrats! Whats essential here is regular posting off good quality blogs.
So start writing ! Tell us about your life, passion, animals or your work.
That Will attract possible followers.
Do be carefull with your passwords, they are yours and yours only.
Look up the free Steemify app in the Appstore or read this blog https://steemit.com/busy/@exyle/using-steemify-to-stay-up-to-date-about-the-blockchain-like-project-destiny-please-consider-blockbrothers-for-your-witness-vote Thats helpfull too.
Next to Steemify I use Appics and Partiko to post.

You can also visit our discord server The Steem Terminal is your one-stop location for learning about destinations on the Steem Blockchain & Discord. Here you will find people who are willing to answer the questions you may have as a new Steemian, documents to assist you, a place to learn and practice, and find out about the many opportunities to connect with other Steemians! Or the account @heyhaveyamet ( a coop with @xcountytravelers ) Where we highlight newcomers.
Oh snd My friend @medro-Martin Will be interested
Hope this helps for now. Good luck, and Full Steem Ahead! Let me know if you have questions,

Love from the Netherlands
Britt

Dope imma follow you, this will be interesting and welcome to steemit.

Posted using Partiko iOS

Thank you! I contemplating next weeks post. Think I will have a very interesting one...........

Hello chemicalweek, welcome to Partiko, an amazing community for crypto lovers! Here, you will find cool people to connect with, and interesting articles to read!

You can also earn Partiko Points by engaging with people and bringing new people in. And you can convert them into crypto! How cool is that!

Hopefully you will have a lot of fun using Partiko! And never hesitate to reach out to me when you have questions!

Cheers,
crypto.talk
Creator of Partiko

Hello and welcome to Steemit @chemicalweek,
wish you much fun and success !
You heard of Partiko already?
A beautiful Steemit app, easy for posting and you can earn Partiko points as well, you can change them into Steem.
Only for sign up you get 1000 points, here is my link to download :
https://partiko.app/referral/zanoni


Welcome to Steemit @chemicalweek!

I wish you much success and hope you find Steemit to be as rewarding and informative as I have.

Here are some links you might find useful.
Your stats on SteemNow
Your stats on SteemWorld
Your stats on SteemD
How does Steemit actually work?

Oh yea, I have upvoted you and followed you. Many blessings!





This post has been voted on by the SteemSTEM curation team and voting trail in collaboration with @curie.

If you appreciate the work we are doing then consider voting both projects for witness by selecting stem.witness and curie!

For additional information please join us on the SteemSTEM discord and to get to know the rest of the community!

Hello @chemicalweek

Welcome to Steemit & Wish you luck - success with Steemit!

Currently, We're supporting for the Planktons by our small upvote. If you follow @haccolong you will get free upvote of 20 users. You may like it, Check statement here.

To get more 15SP delegate + 3000points and receive additional rewards from your activities on Steemit, you can use Partiko app for your phone.

Please ignore this reply if you do not need the above.

Posted using Partiko Android

Good luck with this project! Feel free to get more information on how to use markdown or HTML to format your posts better, to make them more appealing for the readers! :)

PS: And feel free to ask questions if needed.

Hello and thank you for joining,

don't get discouraged and

Steem on

Chapper

I dont think I will get discouraged! Thank you!

Post via steemstem.io for the additional upvote from STEM community

And find us on Discord

https://discord.gg/dczafA

Welcome chemicalweek!
eSteem is the application that improves your experience on Steem. You have full control over your data and content, unlike some apps we don't use our users to promote our application or services.

We have Mobile application for Android and iOS users. We also have developed Surfer Desktop application that helps you to gain new followers and stay connected with your friends, unique features - notifications, bookmarks, favorites, drafts, and more.
We reward our users with encouragement upvotes as well as monthly giveaways rewarding Spotlight top users and active Discord users.
Learn more: https://esteem.app
Join our discord: https://discord.gg/8eHupPq

Hi and welcome here! When I started on steemit, my biggest problem was to find interesting people to interact with. So, to help newcomers getting started I created a directory with other interesting and or talented steemians to follow or interact with. Feel free to check it out at https://www.steemiandir.com I am sure it will help you find like-minded people. Enjoy your stay here and do not hesitate to contact me if you have any questions!

Hi and welcome here! When I started on steemit, my biggest problem was to find interesting people to interact with. So, to help newcomers getting started I created a directory with other interesting and or talented steemians to follow or interact with. Feel free to check it out at https://www.steemiandir.com I am sure it will help you find like-minded people. Enjoy your stay here and do not hesitate to contact me if you have any questions!

Welcome to Steem chemicalweek! Partiko is officially the fastest and most popular mobile app for Steem. Unlike other Steem apps, we take 0% cut of your earnings! You can also be rewarded with Partiko Points while using Partiko and exchange Partiko Points for upvotes!

Partiko for Android can be downloaded here on Google Play and the iOS version is available here on the App Store.

If you have more questions, feel free to join our Discord channel and ask @crypto.talk, we're always here to help!

Thank you so much for your interest!

Hello welcome to Steem. Steem is home to very rewarding applications, top of the list is partiko and Actifit.

You can get started with partiko by downloading the app:
https://partiko.app/referral/akomoajong

You can equally started earning with actifit by downloading the app and post your daily fitness level acquired.

You post will be upvoted and rewarded with AFIT Tokens. 1 AFIT Tokens is currently $0.036 and you get at least 25 for reaching 5,000 counts on the tracker.

Download the app from play store and start earning;

Android: http://bit.ly/2CLWDqT

iOS: http://bit.ly/actifit-ios

You can always reach out to me for any help or assistance.

Yours,

Akomo Ajong

Actifit Ambassador

Partiko Promoter

Posted using Partiko Android

Welcome to steemit @chemicalweek.

Welcome the new steemians. Have a great day!

Congratulations @chemicalweek! You have completed the following achievement on the Steem blockchain and have been rewarded with new badge(s) :

You published your First Post
You got a First Vote
You received more than 500 upvotes. Your next target is to reach 1000 upvotes.
You made your First Vote
You made your First Comment
You got a First Reply
You made more than 10 upvotes. Your next target is to reach 50 upvotes.

You can view your badges on your Steem Board and compare to others on the Steem Ranking
If you no longer want to receive notifications, reply to this comment with the word STOP

To support your work, I also upvoted your post!

Do not miss the last post from @steemitboard:

3 years on Steem - The distribution of commemorative badges has begun!
Happy Birthday! The Steem blockchain is running for 3 years.
Vote for @Steemitboard as a witness to get one more award and increased upvotes!

Congratulations @chemicalweek!
Your post was mentioned in the Steem Hit Parade for newcomers in the following categories:

  • Upvotes - Ranked 3 with 679 upvotes
  • Comments - Ranked 7 with 18 comments

I also upvoted your post to increase its reward
If you like my work to promote newcomers and give them more visibility on the Steem blockchain, consider to vote for my witness!