You should walk on eggshells on this topic nowadays; chromosomes are increasingly considered irrelevant compared to one's own personal choices, and there are also others such as xxy xxx or whatever... worth a post in themselves!
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You mean the Jenners of this world? 😅
Trisomy and monosomy conditions. These happen when there are aberrations during the formation of gametes. I think I wrote a piece on this a while back. Might write another one.