It seems like a terrifying disease, for certain. Are you familiar with Max Lugavere? Interesting story, his mom was diagnosed with early on-set Alzheimer's in her 50s and he got into this whole rabbithole trying to figure out wtf happened, now he's heavily into nutrition and diet and how to eat (and live) to hopefully prevent it. According to a course I took with him, at least 40% of Alzheimer's cases in the US are preventable. I don't know if that's true, obviously, but it does seem heavily linked with the shit we're consuming nonstop. Obviously, diet isn't a magic problem-solver, but it tends to go hand in hand with other factors like getting more exercise, minding your sleep, your use of toxic cosmetics etc.
Fascinating (and frightening) stuff!
Yes, I have listened to an interview with him! I was impressed with how much he was able to unearth on it, but you start to think that it's such a shame this wasn't more widely known before his mother reached that point. He's certainly not the only one to end up going down rabbitholes due to a parent having one of the mitochondrial disfunction outcomes and it's those people who are doing their best to try and get the information out there so others don't have to experience the same.
We have such a cascade of things going wrong in our modern life and only so much that is within our control to change. I think exercise is a word that puts people off doing anything in that regard, yet any regular movement is really all that's needed to make an improvement on mitochondrial function. Even school starts us off on a path away from that, when we have to stop fidgeting and sit still.