It depends. Do you want to repair your inner tyre? If so, you can leave it all tightened up.
If you need to replace it is a bit more difficult.
You need to get the inner tube past your axis. There is a tool that can spread your frame a bit so you can replace your inner tube. It is a bit of a job though. You can leave your derailler attached and 'insert' your tube on the other side.

You can contact me on Discord too if you need some more info. It is a bit hard explaining it in a comment 😉

https://www.icetoolz.eu/en/icetoolz-frame-fork-adjuster-e263/a5743