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Yes, but Rep is not really a measure of anything here. High rep doesn't mean that much in terms of "trustworthiness" neither does life rep. More importantly, it has no on chain effect.

So in essence, it is not really something that is important to people that would otherwise be anti social anyway!

Being able to force all posts and comments to be hidden if someone's rep dips below (0) is generally considered significant. There are large accounts with high rep that have cashed-out due to downvote harassment (metarzan and fyrestikken and probably others I'm not personally aware of).

Big downvotes will cause people to rage-quit.