Mother (Amy Adams) spends her days raising her two-year-old son, only granted a slight reprieve on the weekends when her husband (Scoot McNairy) returns, largely oblivious to the ways his wife is drowning. As her anger at his ineptitude grows, along with her sense of isolation and loss of sense of self, Mother undergoes a baffling transformation, seemingly becoming (at least in her own mind) a dog who runs through the streets of suburbia at night, howling at the moon.