- The 17th Amendment: Wilson signed the 17th Amendment to the Constitution in 1913, which allowed for the direct election of U.S. Senators.
- The Federal Trade Commission: Wilson signed the Federal Trade Commission Act in 1914, which created the Federal Trade Commission, an independent agency responsible for regulating business practices.
- The Clayton Antitrust Act: Wilson signed the Clayton Antitrust Act in 1914, which strengthened antitrust laws and prohibited certain business practices.
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