These so-called Argonaute syndromes were discovered, where there are mutations in Argonautes, point mutations where only one amino acid changes to another amino acid. They have this very profound and extensive effect on the development of the individual.

And so working with these geneticists, our lab and other labs took those mutations, that were essentially gifted to us by the patient. And then we put those mutations into our system, in our case into C. elegans‘ Argonaute.

I’m excited by the very organized, active partnership between the Argonaute Alliance of families with Argonaute syndromes and the basic scientists studying Argonaute.