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Oprah, who has long been associated with Weight Watchers—a program emphasizing calorie counting, dieting, and lifestyle changes—initially believed that staying thin was primarily a matter of willpower. She previously dismissed medications like OIC as the "easy way out," insisting that true weight loss came from dieting and exercise.

However, her recent confession that she used OIC to shed nearly 50 pounds after decades of yo-yo dieting has surprised many. She admits that the medication played a significant role in her success, marking a stark contrast from her earlier stance. Her experience underscores how powerful and influential these drugs are perceived to be, especially given their approval as effective, medically supervised options for weight management.