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Director Destin Daniel Cretton will helm Spider-Man 4, promising a fresh approach to the series. The plot is known to explore the ramifications of Peter Parker's choices at the conclusion of No Way Home, particularly the spell cast by Doctor Strange that erases his identity from the minds of those he loves. This new direction sets the stage for a tale of loss and solitude for Parker, devoid of friends, allies, and any semblance of his former superhero life.