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In a candid Instagram statement, Gaga explained the significance behind "Disease." She opened up about her ongoing struggles with her inner chaos, writing, “I think a lot about the relationship I have with my own inner demons. It’s never been easy for me to face how I get seduced by chaos and turmoil. 'Disease' is about facing that fear, facing myself and my inner Darkness.” This personal revelation highlights the emotional weight and depth of the song, resonating with those who may share similar battles.