I haven't been able to find a single thing that truly helps with POTS. The best I've been able to do is manage symptoms. I take a beta blocker (atenolol) and now an ARB (angiotensin receptor blocker,) and together they seem to have a positive impact, but they come with their own issues and side effects. POTS is a truly debilitating disease, because people who have it are profoundly limited in mobility and activity. Then you have to deal with all the people who say, "just get in shape. You'll be fine." Yeah, if you don't die in the process like I almost did. Water exercise is the only exercise I can tolerate, period. The pressure of the water and the cool temperature encourages blood flow up from the legs and that does help. But as far as anything to make the disease actually "better"... sadly, no. I haven't found a thing.