Cml is a type of cancer stem cells of the hematopoietic system characterized by the abnormal production of immature granulocytes. It is silent in most of the cases because their symptoms are presenting little by little and often become visible in an advanced state, is common in the elderly sick and very rare in young people, as well that I tell you that I won the lottery...
The CML is presented in three phases:
- Chronic phase.
- Accelerated phase.
- Blastic Phase.
Some of the symptoms:
⦁ Tiredness.
⦁ Fatigue.
⦁ weight loss.
⦁ Night Soduraciones .
⦁ gingival bleeding.
⦁ abdominal discomfort.
⦁ massive splenomegaly.
⦁ Bruises
Diagnostic tests:
- Laboratory tests
⦁ Hematology: Study of the different cells of the blood and tissues trainers of the same.
⦁ Biopsy: The removal of tissue from the bone marrow, to perform a microscopic examination and determine the diagnosis, is carried out by the suction through a fixed needle connected to a inyectadora. (This part if it hurts).
⦁ Cytogenetics: a set of procedures for the realization of chromosome analysis is used to identify genetic abnormalities or in the search for genetic markers of tumors, in this case identifies the translocation of cromosama 9 and 22 resulting in the Philadelphia chromosome, is present in 95% of patients. The remaining patients have a variant.
⦁ QPCR: Are modern methodologies for the study of gene expression.
⦁ Diagnosis by Imaging: Chest x-ray and abdominal CT.
⦁ Abdominal Eco: It is necessary to detect any abnormalities in liver and spleen to rule out a possible hepatosplenomegaly (inflammation of liver and spleen).
Treatment:
There are several types of inhibitors that are managed on a continuous basis and for life, among them the most outstanding are:
Imatinib, dasatinib and nilotinib. All three are molecules that have been created specifically to treat the Cml and that do not produce as many side effects as any other chemotherapy, are treatments by mouth of first line, with which there is no cure for the disease, but if you control and allows for a better quality of life with some restrictions, but nothing out of this world.
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I hope this information will be of your liking and that at some point in their lives to provide support to a family member, friend, even to yourself. Then I will tell you how to live from day to day without letting it affect us. A hug of the size of the universe ♥.