Why do some people become addicted to drugs while others do not?

ROLE OF GENETICS IN DRUG
ABUSE AN ADDICTION
 Heritability estimates for nicotine,
alcohol, and drug addiction are in the
range of 50% to 60%.
 Inherited differences among
individuals affect their response to
drugs.

BRAIN DECIDES YOUR LIKING FOR
DRUGS.

Genetics and drugs
 ALCOHOL: ALDH2 is protective as it
causes hypersensitivity to alcohol
 NICOTINE: Gene cluster (CHRNA6,
CHRNB3 on chromosome 8
 NICOTINE: CYP2A6: NICOTINE TO
COTININE
 OPOIDS: OPRM1
 Common genes for nicotine and alcohol:
Alpha4 nicotine receptor
 Common gene for all drugs of abuse”.

ITS’S TRUE THAT PEOPLE MAY
CHOOSE TO TAKE DRUGS, BUT NO
ONE CHOOSES TO BE AN ADDICT
THAT IS ALREADY DECIDED..

…addiction is not about drugs,
it’s about brains.

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