Watford have sacked manager Quique Sanchez Flores after Saturday's 2-1 loss to Southampton, saying "ultimately results have dictated our decision".
Sanchez Flores, who was in charge for the 2015-16 season, was on 7 September, replacing Javi Gracia.
Chris Hughton is a possible successor and the Hornets said a replacement will be appointed "imminently".
"Quique is a man of great integrity and it was clear how much he wanted to have a positive impact, but ultimately results have dictated our decision," said chairman Scott Duxbury.
But he won just one of his 10 league games in charge with Watford bottom of the Premier League.
Watford have eight points after 14 games and are six points from safety - their worst return at this stage of a Premier League campaign.
"The appointment of a new head coach is imminent, and with nearly two-thirds of the season remaining, we will provide all the support necessary to make the coming months successful."