In-N-Out by a landslide. Having been to Five Guys numerous times because of glowing reviews from friends, I have never not been disappointed. Burgers were always soggy with grease (or just soggy in general), their fries are subpar, and their shakes were okay. I'm not the biggest fan of In-N-Out fries, but they're better than Five Guys, and there isn't even a comparison when it comes to burger quality. I'll take In-N-Out all day, every day over Five Guys.