You are using a lot of bio-chemistry terminology which IMO is a minefield of dissinfo and science-waffle. I prefer to ignore them (as they are wrong but cover it up with lots of sciencey words). Maybe you would say I over-simplify too much and maybe you're right but in my world Occams Razor works. If the explanation is too complicated that's because it's wrong. ANY cell can become 'cancerous' and the switch to turn it off and on is in the brain. This is why Henrietta Lacks' cancer cells are still alive today, there is no brain to tell them to turn off.