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ohmigosh, if I did that, I'd NEVER go and clear them out. My basic strategy is to leave everything open for a couple of weeks, then go back through and x out of all that are out-of-date or no longer pertinent.

not very efficient, actually...

I used to have hundreds open. I had a firefox extension that allowed you to group your tabs into topics/categories, and find them that way. But all it really did was allow me to amass more and more tabs. With the new firefox a lot of old extensions stopped working, so I had to delete it. When I did that I just deleted every open tab en masse. Man, that felt SO good.. :D