The obvious choice for me is United vs. Palace. With United in great form and Palace in dismal form, it's safe to expect a total battering.
Choosing a second selection is much harder since the highest goal scorers Man City are facing a pretty solid defense and it's not impossible for the game to be a lower scoring one. So I'm considering Tottenham battering Huddersfield away which they are pretty good at too and Liverpool scoring a lot of goals against Newcastle.
I'm still going to go with Chelsea vs Man City as I think Pep's boys will find a way to score a few while Morata, Hazard and co. could still ship a few at the other end too.
Thank you one more time @rocking-dave for the analysis. I also see the Newcastle game as one with goals :)